The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …

Heart failure plagues industrialized nations, killing more people than any other disease. It
usually results from a deficiency of specialized cardiac muscle cells known as …

Despite preclinical studies demonstrating the functional benefit of transplanting human
pluripotent stem cell-derived cardiomyocytes (PSC-CMs) into damaged myocardium, the …

Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …

Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …

Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Human-induced pluripotent stem cells (hiPSCs) can differentiate into functional
cardiomyocytes; however, the electrophysiological properties of hiPSC-derived …

The immature phenotype of human pluripotent stem cell derived cardiomyocytes (hPSC-
CMs) constrains their potential in cell therapy and drug testing. In this study, we report that …

The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

Background—Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs)
monolayers generated to date display an immature embryonic-like functional and structural …