Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Abstract The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are
members of the basic helix-loop-helix family of transcription factors that control the …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

The genome exists as an organized, three-dimensional (3D) dynamic architecture, and each
cell type has a unique 3D genome organization that determines its cell identity. An …

The genesis of skeletal muscle during embryonic development and postnatal life serves as a
paradigm for stem and progenitor cell maintenance, lineage specification, and terminal …

As we enter the new millennium, the prospects for the field of Biomedical Engineering are
bright. Individuals interested in pursuing careers in this field continue to increase and the …

Mice carrying null mutations in the myogenic regulatory factors Myf-5 or YyoD have
apparently normal skeletal muscle. To address whether these two factors functionally …

The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of
cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted …

Satellite cells are a heterogeneous population of stem and progenitor cells that are required
for the growth, maintenance and regeneration of skeletal muscle. The transcription factors …