Advanced technologies for the development of infectious disease vaccines

A Gupta, A Rudra, K Reed, R Langer… - Nature Reviews Drug …, 2024 - nature.com
Vaccines play a critical role in the prevention of life-threatening infectious disease. However,
the development of effective vaccines against many immune-evading pathogens such as …

Exploring new perspectives in immunology

R Medzhitov, A Iwasaki - Cell, 2024 - cell.com
Several conceptual pillars form the foundation of modern immunology, including the clonal
selection theory, antigen receptor diversity, immune memory, and innate control of adaptive …

Tumor-targeting and activatable biomimetic nanococktails synergistically regulate immune responses for spatiotemporal immunotherapy of low immunogenic solid …

Y Cui, J Liu, L Cui, C Wei, M Xu, Z Wu, Y Guo, P Mi - Nano Today, 2024 - Elsevier
Cancer immunotherapy is generally limited by the low immunogenicity of tumor
microenvironments (TME). Thus, regulating immune responses in low immunogenic solid …

Lung-specific supramolecular nanoparticles for efficient delivery of therapeutic proteins and genome editing nucleases

J Liu, Q Zheng, R Yao, M Wang - Proceedings of the National Academy of …, 2024 - pnas.org
Protein therapeutics play a critical role in treating a large variety of diseases, ranging from
infections to genetic disorders. However, their delivery to target tissues beyond the liver …

Stimuli-Responsive Polymersomes: Reshaping the Immunosuppressive Tumor Microenvironment

Y Wei, X Weng, Y Wang, W Yang - Biomacromolecules, 2024 - ACS Publications
The progression of cancer involves mutations in normal cells, leading to uncontrolled
division and tissue destruction, highlighting the complexity of tumor microenvironments …

[HTML][HTML] Novel administration routes, delivery vectors, and application of vaccines based on biotechnologies: a review

CI Rai, TH Kuo, YC Chen - Vaccines, 2024 - mdpi.com
Traditional vaccines can be classified into inactivated vaccines, live attenuated vaccines,
and subunit vaccines given orally or via intramuscular (IM) injection or subcutaneous (SC) …

Progress and challenges in the clinical evaluation of immune responses to respiratory mucosal vaccines

X Zhang, J Zhang, S Chen, Q He, Y Bai… - Expert Review of …, 2024 - Taylor & Francis
Introduction Following the coronavirus disease pandemic, respiratory mucosal vaccines that
elicit both mucosal and systemic immune responses have garnered increasing attention …

A next-generation inhalable dry powder COVID vaccine

Z Xing, M Jeyanathan - 2023 - nature.com
A next-generation inhalable dry powder COVID vaccine Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Mitophagy-Enhanced Nanoparticle-Engineered Mitochondria Restore Homeostasis of Mitochondrial Pool for Alleviating Pulmonary Fibrosis

Y Wang, LF Hu, NH Liu, JS Yang, L Xing, JH Jeong… - ACS …, 2024 - ACS Publications
Pulmonary fibrosis (PF) is an interstitial lung disease tightly associated with the disruption of
mitochondrial pool homeostasis, a delicate balance influenced by functional and …

[HTML][HTML] From mesenchymal stem cells to their extracellular vesicles: Progress and prospects for asthma therapy

S Chen, J Gao, T Zhang - Asian Journal of Pharmaceutical Sciences, 2024 - Elsevier
Asthma is a widespread public health concern, with an increasing incidence. Despite the
implementation of current treatment strategies, asthma control, particularly for severe cases …