Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …

Ulcerative colitis (UC) specifically affects the colon and rectum through multifactorial
mechanisms associated with genetic alterations, environmental factors, microbiota, and …

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

Opposing roles have been proposed for IL-22 in intestinal pathophysiology. We have
optimized human small intestinal organoid (hSIO) culturing, constitutively generating all …

The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
Crohn's disease (CD). However, as with all complex diseases, robust identification of the …