The chemical inhibitors of endocytosis: from mechanisms to potential clinical applications
OK Szewczyk-Roszczenko, P Roszczenko… - Cells, 2023 - mdpi.com
Endocytosis is one of the major ways cells communicate with their environment. This
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …
HIV-associated neurocognitive disorder
RC Smail, BJ Brew - Handbook of clinical neurology, 2018 - Elsevier
Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) affects
roughly half the HIV-positive population. The symptoms of cognitive slowing, poor …
roughly half the HIV-positive population. The symptoms of cognitive slowing, poor …
Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy
Objective: The aim of this study was to measure the protein concentration and biological
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model
Brain derived neurotrophic factor (BDNF) promotes the growth, differentiation, maintenance
and survival of neurons. These attributes make BDNF a potentially powerful therapeutic …
and survival of neurons. These attributes make BDNF a potentially powerful therapeutic …
Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions
Human immunodeficiency virus (HIV) remains a persistent public health concern throughout
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
Biotypes of HIV-associated neurocognitive disorders based on viral and immune pathogenesis
TP Johnson, A Nath - Current opinion in infectious diseases, 2022 - journals.lww.com
Subtyping patients into subgroups based on biotypes has emerged as a useful approach for
studying heterogeneous diseases. Understanding biotypes of HIV-associated …
studying heterogeneous diseases. Understanding biotypes of HIV-associated …
[HTML][HTML] HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress
The advent of combined antiretroviral treatment (cART) as a treatment for HIV-1 infection has
not only resulted in a dramatic decrease in the peripheral viral load but has also led to …
not only resulted in a dramatic decrease in the peripheral viral load but has also led to …
Shock and kill within the CNS: A promising HIV eradication approach?
MM Nühn, SBH Gumbs, NVEJ Buchholtz… - Journal of Leukocyte …, 2022 - academic.oup.com
The most studied HIV eradication approach is the “shock and kill” strategy, which aims to
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …
Role of pyroptosis in the pathogenesis of various neurological diseases
A Oladapo, T Jackson, J Menolascino… - Brain, Behavior, and …, 2024 - Elsevier
Pyroptosis, an inflammatory programmed cell death process, has recently garnered
significant attention due to its pivotal role in various neurological diseases. This review …
significant attention due to its pivotal role in various neurological diseases. This review …
Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND
J Marino, ME Maubert, AR Mele, C Spector… - Cellular and Molecular …, 2020 - Springer
Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) is a potent
mediator involved in the development of HIV-1-associated neurocognitive disorders …
mediator involved in the development of HIV-1-associated neurocognitive disorders …