Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and
certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally …

All progressive renal diseases are the consequence of a process of destructive fibrosis. This
review will focus on tubulointerstitial fibrosis, the pathophysiology of which will be divided …

Patients with end-stage renal disease suffer from complex hemostatic disorders. Uremic
patients show a bleeding diathesis that is mainly due to abnormalities of primary …

At present, diabetic kidney disease affects about 15–25% of type 1 and 30–40% of type 2
diabetic patients. Several decades of extensive research has elucidated various pathways to …

Platelet-derived growth factor (PDGF) is mainly believed to be an important mitogen for
connective tissue, especially for fibroblasts that serve in wound healing. However, PDGF …

The PDGF system, comprising four isoforms (PDGF-A,-B,-C, and-D) and two receptor chains
(PDGFR-α and-β), plays important roles in wound healing, atherosclerosis, fibrosis, and …

Chronic kidney disease (CKD) is a major health and economic burden with a rising
incidence. During progression of CKD, the sustained release of proinflammatory and …

Expression of platelet-derived growth factor (PDGF) and its receptor (R) subunits was
evaluated in normal human liver and in cirrhotic liver tissue by in situ hybridization and …

Mechanisms involved in the pathogenesis of tubulointerstitial fibrosis in 5/6-nephrectomized
rats. The 5/6 nephrectomy model is used to study pathogenetic mechanisms underlying …