The impaired insulin secretion and increased insulin resistance (or decreased insulin
sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is …

Diabetes mellitus is seen to be prevalent among the different epidemics. The prevalence
rate of the diabetes mellitus is seen to be increasing in different regions of the world. Type 2 …

Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and insulin, are
critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes …

This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive
gene. It also shows that insulin induces substantial expression and secretion of MCP-1 both …

Task Forces, expert groups, or consensus panels. The chosen experts in these writing
panels are asked to provide disclosure statements of all relationships they may have, which …

Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) are intermediate states
in glucose metabolism that exist between normal glucose tolerance and overt diabetes …

Ceramides are sphingolipids and integral components of the eukaryotic cell membrane.
Apart from providing structural integrity, ceramides have also been shown to act as second …

Type 2 diabetes frequently results from progressive failure of pancreatic β-cell function in the
presence of chronic insulin resistance. We tested whether chronic amelioration of insulin …

Prevention of type 2 diabetes by intensive lifestyle intervention designed to achieve and
maintain ideal body weight was assessed in subjects with impaired glucose tolerance (IGT) …

There is a progressive deterioration in β-cell function and mass in type 2 diabetics. It was
found that islet function was about 50% of normal at the time of diagnosis, and a reduction in …