Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a
supportive niche. Viewed through the lens of an ecosystem, numerous tumor components …

Mesenchymal stem cells (MSCs) were officially named more than 25 years ago to represent
a class of cells from human and mammalian bone marrow and periosteum that could be …

Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in
secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can …

During the past decade preclinical studies have defined many of the mechanisms used by
tumours to hijack the skeleton and promote bone metastasis. This has led to the …

Pre-metastatic niche formation is critical for the colonization of disseminated cancer cells in
distant organs. Here we find that lung mesenchymal stromal cells (LMSCs) at pre-metastatic …

Pericytes are a heterogeneous population of cells located in the blood vessel wall. They
were first identified in the 19th century by Rouget, however their biological role and potential …

Metastasis is an inefficient process, especially during colonization at a distant organ. This
bottleneck underlies the importance of the metastatic niche for seeding and outgrowth of …

ABSTRACT Human Mesenchymal Stem Cells, hMSCs, were first named over 25 years ago
with the “stem cell” nomenclature derived from the fact that we and others could cause these …

Pericytes are branched cells located in the wall of capillary blood vessels that are found
throughout the body, embedded within the microvascular basement membrane and …