Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment
Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …
Retinal imaging in Alzheimer's disease
Identifying biomarkers of Alzheimer's disease (AD) will accelerate the understanding of its
pathophysiology, facilitate screening and risk stratification, and aid in developing new …
pathophysiology, facilitate screening and risk stratification, and aid in developing new …
Fifteen years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study: progress and observations from 2,359 older adults spanning the spectrum from …
C Fowler, SR Rainey-Smith, S Bird… - Journal of …, 2021 - content.iospress.com
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …
2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild …
Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia
EE Abrahamson, MD Ikonomovic - Experimental Neurology, 2020 - Elsevier
The blood-brain barrier (BBB) is a complex and dynamic physiological interface between
brain parenchyma and cerebral vasculature. It is composed of closely interacting cells and …
brain parenchyma and cerebral vasculature. It is composed of closely interacting cells and …
Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer's disease and vascular cognitive impairment
Background There has been ongoing research impetus to uncover novel blood-based
diagnostic and prognostic biomarkers for Alzheimer's disease (AD), vascular dementia …
diagnostic and prognostic biomarkers for Alzheimer's disease (AD), vascular dementia …
[HTML][HTML] Pathophysiology of dementia
KS Chin - Australian Journal of General Practice, 2023 - racgp.org.au
Background Dementia is a debilitating neurological condition that affects millions of patients
and families worldwide and remains a significant public health concern. Understanding the …
and families worldwide and remains a significant public health concern. Understanding the …
Low Subicular Volume as an indicator of dementia-risk susceptibility in old age
SM Kagerer, C Schroeder, JMG van Bergen… - Frontiers in aging …, 2022 - frontiersin.org
Introduction Hippocampal atrophy is an established Alzheimer's Disease (AD) biomarker.
Volume loss in specific subregions as measurable with ultra-high field magnetic resonance …
Volume loss in specific subregions as measurable with ultra-high field magnetic resonance …
Differential effects of white matter hyperintensities and regional amyloid deposition on regional cortical thickness
White matter hyperintensities (WMH) and β-amyloid (Aβ) accumulation have both been
linked to neurodegeneration in Alzheimer's disease (AD). However, the independent effects …
linked to neurodegeneration in Alzheimer's disease (AD). However, the independent effects …
Additive interaction of mid-to late-life depression and cerebrovascular disease on the risk of dementia: a nationwide population-based cohort study
Background Dementia is a progressive neurocognitive disease with a substantial social
burden. No apparent breakthroughs in treatment options have emerged so far; thus, disease …
burden. No apparent breakthroughs in treatment options have emerged so far; thus, disease …
The role of vascular risk factors in biomarker-based AT (N) groups: a German-Dutch memory clinic study
D Kučikienė, AS Costa, LCP Banning… - Journal of …, 2022 - content.iospress.com
Background: The relation between vascular risk factors (VRFs) and Alzheimer's disease
(AD) is important due to possible pathophysiological association. Objective: To assess the …
(AD) is important due to possible pathophysiological association. Objective: To assess the …