Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural
activity transmitted from the cochlea to the central auditory system. Despite a reduced …

Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Tinnitus, reduced sound-level tolerance, and difficulties hearing in noisy environments are
the most common complaints associated with sensorineural hearing loss in adult …

Tinnitus is the conscious perception of a sound without a corresponding external acoustic
stimulus, usually described as a phantom perception. One of the major challenges for …

Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes …

Hearing loss often triggers an inescapable buzz (tinnitus) and causes everyday sounds to
become intolerably loud (hyperacusis), but exactly where and how this occurs in the brain is …

In rodents, exposure to high-level noise can destroy synapses between inner hair cells and
auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such …

Abstract The Tinnitus Research Consortium (TRC) issued a Request for Proposals in 2003
to develop a new tinnitus outcome measure that would:(1) be highly sensitive to treatment …

Chronic tinnitus is the persistent sensation of hearing a sound that exists only inside the
head. The prevalence of tinnitus in adults in the United States is estimated at 10 to 15%. For …

The phantom sound of tinnitus is believed to be triggered by aberrant neural activity in the
central auditory pathway, but since this debilitating condition is often associated with …