Toxoplasma gondii infection and its implications within the central nervous system

SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

[HTML][HTML] Control of human toxoplasmosis

NC Smith, C Goulart, JA Hayward, A Kupz… - International journal for …, 2021 - Elsevier
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …

Drugs in development for toxoplasmosis: advances, challenges, and current status

PH Alday, JS Doggett - Drug design, development and therapy, 2017 - Taylor & Francis
Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are
currently used to treat toxoplasmosis commonly have toxic side effects and require …

Treatment of toxoplasmosis: Current options and future perspectives

N Konstantinovic, H Guegan, T Stäjner, S Belaz… - Food and waterborne …, 2019 - Elsevier
Toxoplasmosis is a worldwide parasitic disease infecting about one third of humans, with
possible severe outcomes in neonates and immunocompromised patients. Despite …

HDAC8: a multifaceted target for therapeutic interventions

A Chakrabarti, I Oehme, O Witt, G Oliveira… - Trends in …, 2015 - cell.com
Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic
target in various diseases, including cancer, X-linked intellectual disability, and parasitic …

In vitro production of cat-restricted Toxoplasma pre-sexual stages

AV Antunes, M Shahinas, C Swale, DC Farhat… - Nature, 2024 - nature.com
Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely
uncharted owing to ethical concerns regarding the use of cats as model organisms …

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

L Braun, MP Brenier-Pinchart, M Yogavel… - Journal of Experimental …, 2013 - rupress.org
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
protozoan parasite that resides inside a parasitophorous vacuole. During infection …

Mechanisms of Toxoplasma gondii persistence and latency

WJ Sullivan Jr, V Jeffers - FEMS microbiology reviews, 2012 - academic.oup.com
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic
disease, particularly in immunocompromised individuals. Central to its transmission and …

The molecular biology and immune control of chronic Toxoplasma gondii infection

XY Zhao, SE Ewald - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist
within cells for the life of the host. Remarkably, at least 350 host species of T. gondii have …

Animals are key to human toxoplasmosis

D Schlüter, W Däubener, G Schares, U Groß… - International Journal of …, 2014 - Elsevier
Toxoplasma gondii is an extremely sucessfull protozoal parasite which infects almost all
mamalian species including humans. Approximately 30% of the human population …