Background In this review, we examine the continually expanding and increasingly
compelling data linking radiation and various chemicals in our environment to the current …

Background There is substantial variability in cancer risk in women who have inherited a
BRCA1 or BRCA2 (BRCA1/2) mutation. Numerous factors have been hypothesized to …

BACKGROUND The effects of controlled ovarian hyperstimulation (COH) for IVF in terms of
breast cancer risk remain controversial, despite the hormone-dependent nature of the latter …

STUDY QUESTION How do couples with a BRCA1/2 mutation decide on preimplantation
genetic diagnosis (PGD) and prenatal diagnosis (PND) for hereditary breast and ovarian …

Breast cancer remains the most common cancer diagnosed in women and causes more lost
disability-adjusted life years (DALYs) than any other cancer worldwide; however …

Primordial follicles or non-growing follicles (NGFs) are the functional unit of reproduction,
each comprising a single germ cell surrounded by supporting somatic cells. NGFs constitute …

Deleterious mutations in BRCA1 or BRCA2 genes have long been recognized as
independent risk factors, mostly for breast and ovarian cancer. Numerous studies have …

Fertility preservation is an important issue for young women diagnosed with breast cancer.
The most well-established options for fertility preservation in cancer patients, embryo and …

Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the difficulties in fertility preservation for women with BRCA positive/negative breast cancer …

Fertility issues have become critical in the management and counseling of BRCA mutation
carriers. In this setting four points deserve consideration.(1) Women in general lose their …