Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR)
signaling field. However, interest in neutrophil biology has been revitalized by emerging …

Streptococcus pneumoniae is the leading cause of community-acquired pneumonia and
sepsis, with adult hospitalization linked to approximately 19% incidence of an adverse …

Cardiac dysfunction is a major consequence of sepsis/septic shock and contributes to the
high mortality of sepsis. Innate and inflammatory responses mediated by TLRs play a critical …

Background. Cardiac dysfunction is present in> 40% of sepsis patients and is associated
with mortality rates of up to 70%. Recent evidence suggests that glycolytic metabolism plays …

Cardiomyocyte inflammation followed by apoptosis and fibrosis is an important mediator for
development and progression of heart failure. Activation of toll-like receptor 4 (TLR4), an …

Emerging studies suggest that monocytes can be trained by bacterial endotoxin to adopt
distinct memory states ranging from low-grade inflammation to immune exhaustion. While …

Hyperglycemia, obesity and metabolic syndrome are negative prognostic factors in breast
cancer patients. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment …

Background This study examined the effect of microRNA-125b (miR-125b) on sepsis-
induced cardiac dysfunction. Methods Mouse hearts were transfected with lentivirus …

Significance: Sepsis is a critical clinical syndrome with life-threatening organ dysfunction
induced by a dysregulated host response to infection. Despite decades of intensive …

Toll‐like receptors (TLRs) are a member of the innate immune system. TLRs detect invading
pathogens through the pathogen‐associated molecular patterns (PAMPs) recognition and …