In this review, we describe the evolutionary process involved in the discovery of the selective
5-HT uptake inhibitor, fluoxetine, and summarize some of the large body of scientific …

The serotonergic system plays a key modulatory role in the brain and is the target for many
drug treatments for brain disorders either through reuptake blockade or via interactions at …

An aversion to harming others is a core component of human morality and is disturbed in
antisocial behavior [1–4]. Deficient harm aversion may underlie instrumental and reactive …

OBJECTIVE: The serotonin system is believed to play a role in modulating impulsivity and
violence. Previous imaging studies have implicated the anterior cingulate and orbitofrontal …

Women and men differ in serotonin associated psychiatric conditions, such as depression,
anxiety and suicide. Despite this, very few studies focus on sex differences in the serotonin …

INTRODUCTION: The primary approach in assessing the status of brain serotonin neurons
in human conditions such as major depression and exposure to the illicit drug ecstasy has …

Alterations of serotonin transporters (SERT) are implicated in a large number of psychiatric
conditions. 11C-(+)-6β-(4-Methylthiophenyl)-1, 2, 3, 5, 6α, 10β-hexahydropyrrolo [2, 1-a] …

The recent introduction of a number of new radiotracers suitable for imaging the serotonin
transporters (SERT) has radically changed the field of SERT imaging. Whereas, until …

11C-N, N-Dimethyl-2-(2-amino-4-methylphenylthio) benzylamine (11C-MADAM) is a newly
synthesized radioligand with high selectivity and specificity for the serotonin transporter (5 …

Parametric imaging of serotonin transporters (SERT) with 11C-labeled 3-amino-4-(2-
dimethylaminomethyl-phenylsulfanyl) benzonitrile ([11C] DASB) PET is a useful data …