The polycation polyethylenimine (PEI) has recently been widely employed for the design of
DNA delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

The transfer of nucleic acids (DNA or RNA) into living cells, that is, transfection, is a major
technique in current biochemistry and molecular biology. This process permits the selective …

Many tumors express tumor-specific antigens capable of being presented to CD8+ T cells by
major histocompatibility complex (MHC) class I molecules. Antigen presentation models …

Gene delivery to skeletal muscle is a promising strategy for the treatment of muscle
disorders and for the systemic secretion of therapeutic proteins. However, present DNA …

There has been keen interest in the development of a novel drug delivery system. Novel
drug delivery system aims to deliver the drug at a rate directed by the needs of the body …

Direct gene transfer offers the potential to introduce DNA encoding therapeutic proteins to
treat human disease. Previously, gene transfer in humans has been achieved by a cell …

Development of an efficient method for introducing a therapeutic gene into target cells in
vivo is the key issue in treating genetic and acquired diseases by gene therapy. To this end …

Abstract Drew Pardoll (Johns Hopkins Oncology Center) examines prospects for therapeutic
cancer vaccines. Considering how it is that the immune system fails to recognize and …

Many specialists are not familiar with both drug delivery and the molecular biology of DNA
vectors. Liposomes in Gene Delivery covers both-molecular biologists will gain a basic …

Although most research on gene therapy has focused on the use of recombinant viruses to
deliver genes to cells in vivo, progress also has been made toward developing nonviral …