Mucus is integral to gut health and its properties may be affected in neurological disease.
Mucus comprises a hydrated network of polymers including glycosylated mucin proteins. We …

The immune and nervous systems are tightly integrated, with each system capable of
influencing the other to respond to infectious or inflammatory perturbations of homeostasis …

MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical
activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven …

Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic
group of diseases or conditions that share common inflammatory pathways, and for which …

Nitrergic enteric neurons are key players of the descending inhibitory reflex of intestinal
peristalsis, therefore loss or damage of these neurons can contribute to developing …

Current treatments for inflammatory bowel disease (IBD) are often inadequate due to limited
efficacy and toxicity, leading to surgical resection in refractory cases. IBD's broad and …

Background Dysbiosis of the gut microbiota may be involved in the pathogenesis of
inflammatory bowel disease (IBD). However, the mechanisms underlying the role of the …

High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern released by
dying cells to stimulate the immune response. During cell death, HMGB1 is translocated …

The Winnie mouse, carrying a missense mutation in Muc2, is a model for chronic intestinal
inflammation demonstrating symptoms closely resembling inflammatory bowel disease …

Ulcerative colitis (UC) and Crohn's disease (CD) are pathological conditions with an
unknown aetiology that are characterised by severe inflammation of the intestinal tract and …