Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …

Preterm birth (PTB) is one of the major health-care challenges of our time. Being born too
early is associated with major risks to the child with potential for serious consequences in …

Background Twin studies have revealed a significant contribution of the fetal genome to risk
of preterm birth. Preterm premature rupture of membranes (PPROM) is the leading …

Gene regulation is essential to placental function and fetal development. We built a genome-
scale transcriptional regulatory network (TRN) of the human placenta using digital genomic …

Preterm birth occurs worldwide and is associated with high morbidity, mortality, and
economic cost. Although several risk factors associated with parturition and preterm birth …

We conducted integrated transcriptomics network analyses of miRNA and mRNA
interactions in human myometrium to identify novel molecular candidates potentially …

Objectives Pregnant women are more susceptible to certain infections; however, this
increased susceptibility is not fully understood. Herein, systems biology approaches were …

There is increased recognition that preterm neonates require sequential surveillance to
capture the spectrum of coordination, communication, learning, and behavior regulation …

Background Complex traits typically involve diverse biological pathways and are shaped by
numerous genetic and environmental factors. Pregnancy-associated traits and pathologies …

We posit the likely architecture of complex diseases is that subgroups of patients share
variants in genes in specific networks which are sufficient to give rise to a shared phenotype …