Despite the availability of over 30 antiseizure medications (ASMs), there is no “one size fits it
all,” so there is a continuing search for novel ASMs. There are divergent data demonstrating …

Serotonin syndrome (SS) is a drug‑induced, potentially fatal, clinical syndrome resulting
from drugs that have serotonergic properties. Several antiepileptic drugs (AEDs) are known …

Depression is a disease with several molecular mechanisms involved, such as problems in
the serotonergic pathway. This disease is very complex and prevalent, and thus important to …

Background Lamotrigine is not recommended in the prevention of migraine in general but
some reports suggest that it might be effective for treating specifically migraine with aura …

High levels of oxidative stress are implicated in hypoxia, a physiological response to low
levels of oxygen. Evidence supports a connection between this response and depression …

In the current study, a series of Schiff base derivatives of lamotrigine are complexed with
zinc, copper, silver, and tin and characterized by spectroscopic techniques and biological …

Trigeminal neuralgia (TN) is a syndrome characterized by recurrent paroxysms of
neuropathic pain in the area of somatosensitive innervation of the trigeminal nerve. TN is …

The prevalence of serotonin syndrome increases over the past several years as more
serotonergic medications are being used in clinical practice. It is a potentially lethal …

Escitalopram is one of selective serotonin reuptake inhibitor antidepressants. As an S-
enantiomer of citalopram, it shows better therapeutic outcome in depression and anxiety …

Amitriptyline, a tricyclic antidepressant, is commonly used to treat depression and
neuropathic pain, but its mechanism is still unclear. We tested the effect of amitriptyline on 5 …