Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

Alzheimer's disease (AD) is the most common neurodegenerative disorder where the
accumulation of amyloid plaques and the formation of tau tangles are the prominent …

Immune infiltration of peripheral natural killer (NK) cells in the brain has been observed in
Alzheimer's disease (AD). Immunity-related genes (IRGs) play an essential role in immune …

Background Using interpretable machine learning, we sought to define the immune
microenvironment subtypes and distinctive genes in AD. Methods ssGSEA, LASSO …

For decades, it has been widely believed that the blood–brain barrier (BBB) provides an
immune privileged environment in the central nervous system (CNS) by blocking peripheral …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide. With
the increasing trend of population aging, the estimated number of AD continues to climb …