Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non‐traditional microorganisms

P Calero, PI Nikel - Microbial Biotechnology, 2019 - Wiley Online Library
The last few years have witnessed an unprecedented increase in the number of novel
bacterial species that hold potential to be used for metabolic engineering. Historically …

Recent advances and state-of-the-art strategies in strain and process engineering for biobutanol production by Clostridium acetobutylicum

C Xue, J Zhao, L Chen, ST Yang, F Bai - Biotechnology advances, 2017 - Elsevier
Butanol as an advanced biofuel has gained great attention due to its environmental benefits
and superior properties compared to ethanol. However, the cost of biobutanol production via …

Metabolic engineering for sustainability and health

GB Kim, SY Choi, IJ Cho, DH Ahn, SY Lee - Trends in Biotechnology, 2023 - cell.com
Bio-based production of chemicals and materials has attracted much attention due to the
urgent need to establish sustainability and enhance human health. Metabolic engineering …

Progress of acetone-butanol-ethanol (ABE) as biofuel in gasoline and diesel engine: A review

I Veza, MFM Said, ZA Latiff - Fuel Processing Technology, 2019 - Elsevier
The properties of butanol offer more promising results compared to those of lower chain
alcohol such as methanol or ethanol. However, butanol as a biofuel has not yet been …

Biotechnological potential and applications of microbial consortia

X Qian, L Chen, Y Sui, C Chen, W Zhang, J Zhou… - Biotechnology …, 2020 - Elsevier
Recent advances in microbial consortia present a valuable approach for expanding the
scope of metabolic engineering. Systems biology enable thorough understanding of diverse …

Prospective and development of butanol as an advanced biofuel

C Xue, XQ Zhao, CG Liu, LJ Chen, FW Bai - Biotechnology advances, 2013 - Elsevier
Butanol has been acknowledged as an advanced biofuel, but its production through acetone–
butanol–ethanol (ABE) fermentation by clostridia is still not economically competitive, due to …

Bacterial Genome Editing with CRISPR-Cas9: Deletion, Integration, Single Nucleotide Modification, and Desirable “Clean” Mutant Selection in Clostridium beijerinckii …

Y Wang, ZT Zhang, SO Seo, P Lynn, T Lu… - ACS synthetic …, 2016 - ACS Publications
CRISPR-Cas9 has been demonstrated as a transformative genome engineering tool for
many eukaryotic organisms; however, its utilization in bacteria remains limited and …

Towards continuous industrial bioprocessing with solventogenic and acetogenic clostridia: challenges, progress and perspectives

CA Vees, CS Neuendorf, S Pflügl - Journal of Industrial …, 2020 - academic.oup.com
The sustainable production of solvents from above ground carbon is highly desired. Several
clostridia naturally produce solvents and use a variety of renewable and waste-derived …

Metabolic engineering of microorganisms for biofuel production

P Majidian, M Tabatabaei, M Zeinolabedini… - … and Sustainable Energy …, 2018 - Elsevier
Microorganisms directly and indirectly contribute to production of diverse biofuels.
Heterotrophic microorganisms are being used for commercial production of biofuels such as …