Maintenance of genome stability is a crucial priority for any organism. To meet this priority,
robust signalling networks exist to facilitate error-free DNA replication and repair. These …

CXCL1 is a CXC chemokine, CXCR2 ligand and chemotactic factor for neutrophils. In this
paper, we present a review of the role of the chemokine CXCL1 in physiology and in …

ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the
LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The …

Interstitial fibrosis is the key pathological characteristics of chronic kidney diseases (CKD). In
this study, we reported that hederagenin (HDG) can effectively improve the renal interstitial …

Serotonin is a highly conserved and ubiquitous signaling molecule involved in a vast variety
of biological processes. A majority of serotonin is produced in the gastrointestinal …

In recent years it has become apparent that the epithelium is highly involved in inflammatory
bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are …

During infection, pathogen sensing and cytokine signaling by the host induce expression of
antimicrobial proteins and specialized post-translational modifications. One such protein is …

Background The epithelium in the colonic mucosa is implicated in the pathophysiology of
various diseases, including inflammatory bowel diseases and colorectal cancer. Intestinal …

The gastrointestinal tract is a highly complex microenvironment under constant interaction
with potentially harmful pathogens. Inflammatory bowel disease (IBD) is an archetypical …

Immune regulation plays a crucial role in human health and disease. Inflammatory bowel
disease (IBD) is a chronic relapse bowel disease with an increasing incidence worldwide …