[HTML][HTML] The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile

MT Fatima, AA Bhat, S Nisar, KA Fakhro, ASAS Akil - Heliyon, 2023 - cell.com
Healthy diet is vital to cellular health. The human body succumbs to numerous diseases
which afflict severe economic and psychological burdens on the patient and family …

[HTML][HTML] New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease

B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action

S La Manna, C Di Natale, V Panzetta, M Leone… - Inorganic …, 2023 - ACS Publications
The physical and chemical properties of paddlewheel diruthenium compounds are highly
dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare …

Glucosyl platinum (II) complexes inhibit aggregation of the C-terminal region of the Aβ peptide

S La Manna, M Leone, I Iacobucci… - Inorganic …, 2022 - ACS Publications
Neurodegenerative diseases are often caused by uncontrolled amyloid aggregation. Hence,
many drug discovery processes are oriented to evaluate new compounds that are able to …

[HTML][HTML] FapA is an intrinsically disordered chaperone for Pseudomonas functional amyloid FapC

HØ Rasmussen, A Kumar, B Shin, F Stylianou… - Journal of Molecular …, 2023 - Elsevier
Bacterial functional amyloids contribute to biofilm development by bacteria and provide
protection from the immune system and prevent antibiotic treatment. Strategies to target …

Enhancing the therapeutic effect in Alzheimer's disease drugs: The role of Polypharmacology and Cholinesterase inhibitors

MM Martins, PS Branco, LM Ferreira - ChemistrySelect, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a devastating syndrome that accounts for 60–70% of all
dementia cases, putting an enormous burden on global healthcare and economy …

Polyisobutylene-based glycopolymers as potent inhibitors for in vitro insulin aggregation

A Dey, U Haldar, T Rajasekhar, P Ghosh… - Journal of Materials …, 2022 - pubs.rsc.org
A family of amphiphilic diblock copolymers containing a hydrophobic polyisobutylene (PIB,
Mn= 1000 g mol− 1) segment and a hydrophilic block with sugar pendants has been …

Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review

D Aryal, S Joshi, NK Thapa, P Chaudhary… - Food Science & …, 2024 - Wiley Online Library
In the middle of an ever‐changing landscape of diabetes care, precision medicine, and
lifestyle therapies are becoming increasingly important. Dietary polyphenols are like hidden …

Structural, kinetic, and thermodynamic aspects of insulin aggregation

C Panda, S Kumar, S Gupta, LM Pandey - … Chemistry Chemical Physics, 2023 - pubs.rsc.org
Given the significance of protein aggregation in proteinopathies and the development of
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …

Enhancing anti-amyloidogenic properties and antioxidant effects of Scutellaria baicalensis polyphenols through novel nanoparticle formation

S Jalili, M Panji, M Mahdavimehr, AM Ahangar… - International Journal of …, 2024 - Elsevier
Protein aggregation and oxidative stress have gained significant research attention due to
their association with a group of diseases known as amyloidosis. Among the strategies …