[HTML][HTML] The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile
Healthy diet is vital to cellular health. The human body succumbs to numerous diseases
which afflict severe economic and psychological burdens on the patient and family …
which afflict severe economic and psychological burdens on the patient and family …
[HTML][HTML] New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease
B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …
A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action
S La Manna, C Di Natale, V Panzetta, M Leone… - Inorganic …, 2023 - ACS Publications
The physical and chemical properties of paddlewheel diruthenium compounds are highly
dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare …
dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare …
Glucosyl platinum (II) complexes inhibit aggregation of the C-terminal region of the Aβ peptide
S La Manna, M Leone, I Iacobucci… - Inorganic …, 2022 - ACS Publications
Neurodegenerative diseases are often caused by uncontrolled amyloid aggregation. Hence,
many drug discovery processes are oriented to evaluate new compounds that are able to …
many drug discovery processes are oriented to evaluate new compounds that are able to …
[HTML][HTML] FapA is an intrinsically disordered chaperone for Pseudomonas functional amyloid FapC
Bacterial functional amyloids contribute to biofilm development by bacteria and provide
protection from the immune system and prevent antibiotic treatment. Strategies to target …
protection from the immune system and prevent antibiotic treatment. Strategies to target …
Enhancing the therapeutic effect in Alzheimer's disease drugs: The role of Polypharmacology and Cholinesterase inhibitors
MM Martins, PS Branco, LM Ferreira - ChemistrySelect, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a devastating syndrome that accounts for 60–70% of all
dementia cases, putting an enormous burden on global healthcare and economy …
dementia cases, putting an enormous burden on global healthcare and economy …
Polyisobutylene-based glycopolymers as potent inhibitors for in vitro insulin aggregation
A family of amphiphilic diblock copolymers containing a hydrophobic polyisobutylene (PIB,
Mn= 1000 g mol− 1) segment and a hydrophilic block with sugar pendants has been …
Mn= 1000 g mol− 1) segment and a hydrophilic block with sugar pendants has been …
Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review
D Aryal, S Joshi, NK Thapa, P Chaudhary… - Food Science & …, 2024 - Wiley Online Library
In the middle of an ever‐changing landscape of diabetes care, precision medicine, and
lifestyle therapies are becoming increasingly important. Dietary polyphenols are like hidden …
lifestyle therapies are becoming increasingly important. Dietary polyphenols are like hidden …
Structural, kinetic, and thermodynamic aspects of insulin aggregation
Given the significance of protein aggregation in proteinopathies and the development of
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …
Enhancing anti-amyloidogenic properties and antioxidant effects of Scutellaria baicalensis polyphenols through novel nanoparticle formation
S Jalili, M Panji, M Mahdavimehr, AM Ahangar… - International Journal of …, 2024 - Elsevier
Protein aggregation and oxidative stress have gained significant research attention due to
their association with a group of diseases known as amyloidosis. Among the strategies …
their association with a group of diseases known as amyloidosis. Among the strategies …