Convolutional neural network for efficient estimation of regional brain strains
Head injury models are important tools to study concussion biomechanics but are
impractical for real-world use because they are too slow. Here, we develop a convolutional …
impractical for real-world use because they are too slow. Here, we develop a convolutional …
Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons
E Barrio-Alonso, A Hernández-Vivanco, CC Walton… - Scientific reports, 2018 - nature.com
Cell cycle reentry followed by neuronal hyperploidy and synaptic failure are two early
hallmarks of Alzheimer's disease (AD), however their functional connection remains …
hallmarks of Alzheimer's disease (AD), however their functional connection remains …
[HTML][HTML] Modeling neurodegeneration in silico with deep learning
Deep neural networks, inspired by information processing in the brain, can achieve human-
like performance for various tasks. However, research efforts to use these networks as …
like performance for various tasks. However, research efforts to use these networks as …
[PDF][PDF] Machine learning in healthcare diagnosis
S Muthukumarasamy, AK Tamilarasan… - … Mach. Learn. E …, 2020 - researchgate.net
The diagnoses of medical systems are widely applied for fast identification diseases,
remedial, and risk-free treatment for indented diseases. It is also growing technology; even …
remedial, and risk-free treatment for indented diseases. It is also growing technology; even …
Simulation of neuroplasticity in a CNN-based in-silico model of neurodegeneration of the visual system
The aim of this work was to enhance the biological feasibility of a deep convolutional neural
network-based in-silico model of neurodegeneration of the visual system by equipping it …
network-based in-silico model of neurodegeneration of the visual system by equipping it …
Pathological aspects of neuronal hyperploidization in Alzheimer's disease evidenced by computer simulation
E Barrio-Alonso, B Fontana, M Valero… - Frontiers in Genetics, 2020 - frontiersin.org
When subjected to stress, terminally differentiated neurons are susceptible to reactivate the
cell cycle and become hyperploid. This process is well documented in Alzheimer's disease …
cell cycle and become hyperploid. This process is well documented in Alzheimer's disease …
A computational model for pain processing in the dorsal horn following axonal damage to receptor fibers
J Crodelle, PD Maia - Brain Sciences, 2021 - mdpi.com
Computational modeling of the neural activity in the human spinal cord may help elucidate
the underlying mechanisms involved in the complex processing of painful stimuli. In this …
the underlying mechanisms involved in the complex processing of painful stimuli. In this …
Relevance of network topology for the dynamics of biological neuronal networks
Complex random networks provide a powerful mathematical framework to study high-
dimensional physical and biological systems. Several features of network structure (eg …
dimensional physical and biological systems. Several features of network structure (eg …
A high-efficiency model indicating the role of inhibition in the resilience of neuronal networks to damage resulting from traumatic injury
BL Frost, SM Mintchev - Journal of Computational Neuroscience, 2023 - Springer
Recent investigations of traumatic brain injuries have shown that these injuries can result in
conformational changes at the level of individual neurons in the cerebral cortex. Focal …
conformational changes at the level of individual neurons in the cerebral cortex. Focal …
Built to last: functional and structural mechanisms in the moth olfactory network mitigate effects of neural injury
Most organisms suffer neuronal damage throughout their lives, which can impair
performance of core behaviors. Their neural circuits need to maintain function despite injury …
performance of core behaviors. Their neural circuits need to maintain function despite injury …