Convolutional neural network for efficient estimation of regional brain strains

S Wu, W Zhao, K Ghazi, S Ji - Scientific reports, 2019 - nature.com
Head injury models are important tools to study concussion biomechanics but are
impractical for real-world use because they are too slow. Here, we develop a convolutional …

Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons

E Barrio-Alonso, A Hernández-Vivanco, CC Walton… - Scientific reports, 2018 - nature.com
Cell cycle reentry followed by neuronal hyperploidy and synaptic failure are two early
hallmarks of Alzheimer's disease (AD), however their functional connection remains …

[HTML][HTML] Modeling neurodegeneration in silico with deep learning

A Tuladhar, JA Moore, Z Ismail… - Frontiers in …, 2021 - frontiersin.org
Deep neural networks, inspired by information processing in the brain, can achieve human-
like performance for various tasks. However, research efforts to use these networks as …

[PDF][PDF] Machine learning in healthcare diagnosis

S Muthukumarasamy, AK Tamilarasan… - … Mach. Learn. E …, 2020 - researchgate.net
The diagnoses of medical systems are widely applied for fast identification diseases,
remedial, and risk-free treatment for indented diseases. It is also growing technology; even …

Simulation of neuroplasticity in a CNN-based in-silico model of neurodegeneration of the visual system

JA Moore, M Wilms, A Gutierrez, Z Ismail… - Frontiers in …, 2023 - frontiersin.org
The aim of this work was to enhance the biological feasibility of a deep convolutional neural
network-based in-silico model of neurodegeneration of the visual system by equipping it …

Pathological aspects of neuronal hyperploidization in Alzheimer's disease evidenced by computer simulation

E Barrio-Alonso, B Fontana, M Valero… - Frontiers in Genetics, 2020 - frontiersin.org
When subjected to stress, terminally differentiated neurons are susceptible to reactivate the
cell cycle and become hyperploid. This process is well documented in Alzheimer's disease …

A computational model for pain processing in the dorsal horn following axonal damage to receptor fibers

J Crodelle, PD Maia - Brain Sciences, 2021 - mdpi.com
Computational modeling of the neural activity in the human spinal cord may help elucidate
the underlying mechanisms involved in the complex processing of painful stimuli. In this …

Relevance of network topology for the dynamics of biological neuronal networks

SA Mengiste, A Aertsen, A Kumar - bioRxiv, 2021 - biorxiv.org
Complex random networks provide a powerful mathematical framework to study high-
dimensional physical and biological systems. Several features of network structure (eg …

A high-efficiency model indicating the role of inhibition in the resilience of neuronal networks to damage resulting from traumatic injury

BL Frost, SM Mintchev - Journal of Computational Neuroscience, 2023 - Springer
Recent investigations of traumatic brain injuries have shown that these injuries can result in
conformational changes at the level of individual neurons in the cerebral cortex. Focal …

Built to last: functional and structural mechanisms in the moth olfactory network mitigate effects of neural injury

CB Delahunt, PD Maia, JN Kutz - Brain Sciences, 2021 - mdpi.com
Most organisms suffer neuronal damage throughout their lives, which can impair
performance of core behaviors. Their neural circuits need to maintain function despite injury …