[HTML][HTML] Metabolomics and metabolic diseases: where do we stand?
CB Newgard - Cell metabolism, 2017 - cell.com
Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …
or whole organisms, has undergone a rapid technological evolution in the past two decades …
Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis
M Guasch-Ferré, A Hruby, E Toledo, CB Clish… - Diabetes …, 2016 - Am Diabetes Assoc
OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …
studies evaluating metabolite markers identified using high-throughput metabolomics …
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
B Chaurasia, TS Tippetts, R Mayoral Monibas, J Liu… - Science, 2019 - science.org
Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart
disease. By genetically engineering mice, we deleted the enzyme dihydroceramide …
disease. By genetically engineering mice, we deleted the enzyme dihydroceramide …
[HTML][HTML] High-throughput plasma lipidomics: detailed mapping of the associations with cardiometabolic risk factors
High-throughput targeted lipid profiling with liquid chromatography-mass spectrometry (LC-
MS) has been used extensively to identify associations between plasma lipid species and …
MS) has been used extensively to identify associations between plasma lipid species and …
[HTML][HTML] Metabolomics of type 1 and type 2 diabetes
B Arneth, R Arneth, M Shams - International journal of molecular sciences, 2019 - mdpi.com
Type 1 and type 2 diabetes mellitus (DM) are chronic diseases that affect nearly 425 million
people worldwide, leading to poor health outcomes and high health care costs. High …
people worldwide, leading to poor health outcomes and high health care costs. High …
Sphingolipids and phospholipids in insulin resistance and related metabolic disorders
PJ Meikle, SA Summers - Nature Reviews Endocrinology, 2017 - nature.com
Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
Lipidomics: techniques, applications, and outcomes related to biomedical sciences
K Yang, X Han - Trends in biochemical sciences, 2016 - cell.com
Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based
on analytical chemistry principles and technological tools, particularly mass spectrometry …
on analytical chemistry principles and technological tools, particularly mass spectrometry …
[HTML][HTML] Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
[HTML][HTML] Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
VD de Mello, J Paananen, J Lindström, MA Lankinen… - Scientific reports, 2017 - nature.com
Wide-scale profiling technologies including metabolomics broaden the possibility of novel
discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted …
discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted …
[HTML][HTML] A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (C15: 0) and heptadecanoic acid (C17: 0) in health and disease
The role of C17: 0 and C15: 0 in human health has recently been reinforced following a
number of important biological and nutritional observations. Historically, odd chain saturated …
number of important biological and nutritional observations. Historically, odd chain saturated …