Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Tumors evade immune-mediated recognition through multiple mechanisms of immune
escape. On chronic tumor antigen exposure, T cells become dysfunctional/exhausted and …

Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal
centres that allow affinity maturation of antibody responses. Although usually located in …

Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid
tissues, producing long-lived antibody secreting plasma cells and memory B cells, which …

While therapies targeting the co‐inhibitory or immune checkpoint receptors PD‐1 and CTLA‐
4 have shown remarkable success in many cancers, not all patients benefit from these …

Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T
(TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody …

Regulatory T cells prevent the emergence of autoantibodies and excessive IgE, but the
precise mechanisms are unclear. Here, we show that BCL6-expressing Tregs, known as …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent
autoimmune disorders. While the function and molecular regulation of Foxp3+ CD4+ Tregs …