Per gram of tissue, the kidneys are among our most highly perfused organs. Yet the renal
cortex and, in particular, the renal medulla are susceptible to hypoxia. In turn, hypoxia is a …

Acute kidney injury (AKI) is a common complication following cardiac surgery performed on
cardiopulmonary bypass (CPB) and has important implications for prognosis. The aetiology …

MicroComputed Tomography has become the gold standard for studying 3D microscopic
structures nondestructively, and this book provides up-to-date coverage of the modality. The …

Impaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill
patients, which can occur even when systemic parameters, including cardiac output and …

We develop a pseudo-three-dimensional model of oxygen transport for the renal cortex of
the rat, incorporating both the axial and radial geometry of the preglomerular circulation and …

Chronic kidney disease (CKD) is caused by hypoxia in the renal tissue, leading to
inflammation and increased migration of pathogenic cells. Studies showed that leukocytes …

In the vascular system, an extensive network structure provides convective and diffusive
transport of oxygen to tissue. In the microcirculation, parameters describing network …

The renal medulla is prone to hypoxia. Medullary hypoxia is postulated to be a leading
cause of acute kidney injury, so there is considerable interest in predicting the oxygen …

Although kidney oxygen tensions are heterogenous, and mostly below renal vein level, the
nephron is highly dependent on aerobic metabolism for active tubular transport. This …

We have previously developed a three-dimensional computational model of oxygen
transport in the renal medulla. In the present study, we used this model to quantify the …