Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …

Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated
to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve …

Cancers often evade immune surveillance by adopting peripheral tissue–tolerance
mechanisms, such as the expression of programmed cell death ligand 1 (PD-L1), the …

Cushing's disease (CD) is a serious endocrine disorder characterized by chronic
hypercortisolism, or Cushing's syndrome (CS), caused by a corticotroph pituitary tumor …

The fact that many cancer types display transcriptional addiction driven by dysregulation of
oncogenic enhancers and transcription factors has led to increased interest in a group of …

As a catalytic subunit of the positive transcription elongation factor b (P-TEFb), cyclin-
dependent kinase 9 (CDK9) has been demonstrated to contribute to carcinogenesis. This …

Kinases have gained an important place in the list of vital therapeutic targets because of
their overwhelming clinical success in the last two decades. Among various clinically …

Libraries of well-annotated small molecules have many uses in chemical genetics, drug
discovery, and therapeutic repurposing. Multiple libraries are available, but few data-driven …