Uterine aging is an important factor that impacts fertility, reproductive health, and uterus-
related diseases; however, it remains poorly explored. Functionally, these disturbances …

Cancer is a major threat to the lives and health of people around the world, and the
development of effective antitumor drugs that exhibit fewer toxic effects is an important …

The management of breast cancer during pregnancy (PrBC) is a relatively rare indication
and an area where no or little evidence is available since randomized controlled trials …

Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and
repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the …

Cellular senescence leads to decreased tissue regeneration and inflammation and is
associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the …

ABSTRACT ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD+
to protein or nucleic acid substrates. This modification can be removed by several different …

PARP-1 participates in various cellular processes, including gene regulation. In Drosophila,
PARP-1 mutants undergo developmental arrest during larval-to-pupal transition. In this …

Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However,
its clinical application is limited due to severe side effects such as cardiotoxicity. In recent …

Endometrial decidualization refers to a series of morphological changes and functional
remodeling of the uterine endometrium to accept the embryo under the effect of estrogen …

The onset of pregnancy marks the start of offspring development, and represents the key
physiological event that induces re-organization and specialization of breast tissue. Such …