[HTML][HTML] Unveiling uterine aging: much more to learn
Y Wu, M Li, J Zhang, S Wang - Ageing Research Reviews, 2023 - Elsevier
Uterine aging is an important factor that impacts fertility, reproductive health, and uterus-
related diseases; however, it remains poorly explored. Functionally, these disturbances …
related diseases; however, it remains poorly explored. Functionally, these disturbances …
Advances in Development of Selective Antitumor Inhibitors That Target PARP-1
F Liu, J Chen, X Li, R Liu, Y Zhang… - Journal of Medicinal …, 2023 - ACS Publications
Cancer is a major threat to the lives and health of people around the world, and the
development of effective antitumor drugs that exhibit fewer toxic effects is an important …
development of effective antitumor drugs that exhibit fewer toxic effects is an important …
ESMO Expert Consensus Statements on the management of breast cancer during pregnancy (PrBC)
S Loibl, HA Azim Jr, T Bachelot, P Berveiller, A Bosch… - Annals of …, 2023 - Elsevier
The management of breast cancer during pregnancy (PrBC) is a relatively rare indication
and an area where no or little evidence is available since randomized controlled trials …
and an area where no or little evidence is available since randomized controlled trials …
[HTML][HTML] Poly-ADP-ribose polymerase (PARP) inhibitors and ovarian function
J Li, Q Li, L Zhang, S Zhang, Y Dai - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and
repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the …
repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the …
c-Jun N-terminal kinase signaling in cellular senescence
Cellular senescence leads to decreased tissue regeneration and inflammation and is
associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the …
associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the …
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell-and tissue-specific manner
CM Kerr, S Parthasarathy, N Schwarting… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD+
to protein or nucleic acid substrates. This modification can be removed by several different …
to protein or nucleic acid substrates. This modification can be removed by several different …
PARP-1 is a transcriptional rheostat of metabolic and bivalent genes during development
G Bamgbose, A Tulin - Life Science Alliance, 2024 - life-science-alliance.org
PARP-1 participates in various cellular processes, including gene regulation. In Drosophila,
PARP-1 mutants undergo developmental arrest during larval-to-pupal transition. In this …
PARP-1 mutants undergo developmental arrest during larval-to-pupal transition. In this …
PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition
C Huang, X Zhang, S Wang, A Shen, T Xu, Y Hou… - Apoptosis, 2024 - Springer
Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However,
its clinical application is limited due to severe side effects such as cardiotoxicity. In recent …
its clinical application is limited due to severe side effects such as cardiotoxicity. In recent …
RhoB promotes endometrial stromal cells decidualization via semaphorin3A/plexinA4 signaling in early pregnancy
L Xu, YH Li, WJ Zhao, YF Sang, JJ Chen, DJ Li… - …, 2022 - academic.oup.com
Endometrial decidualization refers to a series of morphological changes and functional
remodeling of the uterine endometrium to accept the embryo under the effect of estrogen …
remodeling of the uterine endometrium to accept the embryo under the effect of estrogen …
[HTML][HTML] Gestational breast cancer–a review of outcomes, pathophysiology, and model systems
MK Callaway, CO Dos Santos - Journal of Mammary Gland Biology and …, 2023 - Springer
The onset of pregnancy marks the start of offspring development, and represents the key
physiological event that induces re-organization and specialization of breast tissue. Such …
physiological event that induces re-organization and specialization of breast tissue. Such …