The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …

Aging is associated with significant changes in structure and function of the kidney, even in
the absence of age-related comorbidities. On the macrostructural level, kidney cortical …

The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a
Controversies Conference on glomerular diseases in November 2017. The conference …

As human life expectancy keeps increasing, ageing populations present a growing
challenge for clinical practices. Human ageing is associated with molecular, structural, and …

Kidney biopsy is the gold standard to diagnose membranous nephropathy (MN).
Approximately 70%-80% of patients with primary MN have anti-phospholipase A2 receptor …

Background Membranous nephropathy (MN) is a common cause of proteinuria in patients
receiving a hematopoietic stem cell transplant (HSCT). The target antigen in HSCT …

Glomerulonephritis is a heterogeneous group of disorders that present with a combination of
haematuria, proteinuria, hypertension, and reduction in kidney function to a variable degree …

Background Few studies have evaluated whether histopathologic lesions on kidney biopsy
provide prognostic information beyond clinical and laboratory data. Methods We enrolled …

C3 glomerulonephritis (C3GN) and dense deposit disease comprise the two classes of C3
glomerulopathy. Studies from Europe and Asia have aided our understanding of this …

A kidney biopsy is done to determine the etiology of the glomerulonephritis (GN) and the
severity of the lesion, to identify whether other lesions, related to or not related to the GN, are …