The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential
role in the signaling of numerous cytokines that have been implicated in the pathogenesis of …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known
regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and …

Evidence has accumulated that cytokines have a fundamental role in the differentiation of
memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell …

There is a critical need for safer and more convenient treatments for organ transplant
rejection and autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases …

Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of
numerous cytokines and growth factors involved in the regulation of immunity, inflammation …

Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …

The aim of this study was to examine the tolerability, antitumor activity, and biological effects
of a new schedule of iv recombinant human interleukin 12 (rhIL-12). Twenty-eight patients …

Genetic deficiency of Jak3 leads to abrogation of signal transduction through the common
gamma chain (γc) and thus to immunodeficiency suggesting that specific inhibition of Jak3 …

Leukemia-inhibitory factor (LIF) is a pleiotropic cytokine expressed by multiple tissue types.
The LIF receptor shares a common gp130 receptor subunit with the IL-6 cytokine …