Revisiting the embryogenesis of lip and palate development

NL Hammond, MJ Dixon - Oral Diseases, 2022 - Wiley Online Library
Clefts of the lip and palate (CLP), the major causes of congenital facial malformation
globally, result from failure of fusion of the facial processes during embryogenesis. With a …

Gene regulatory networks and signaling pathways in palatogenesis and cleft palate: a comprehensive review

HJ Won, JW Kim, HS Won, JO Shin - Cells, 2023 - mdpi.com
Palatogenesis is a complex and intricate process involving the formation of the palate
through various morphogenetic events highly dependent on the surrounding context. These …

Molecular and cellular mechanisms of palate development

C Li, Y Lan, R Jiang - Journal of dental research, 2017 - journals.sagepub.com
Development of the mammalian secondary palate involves highly dynamic morphogenetic
processes, including outgrowth of palatal shelves from the oral side of the embryonic …

Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero

S Jia, J Zhou, C Fanelli, Y Wee, J Bonds… - …, 2017 - journals.biologists.com
Clefts of the palate and/or lip are among the most common human craniofacial
malformations and involve multiple genetic and environmental factors. Defects can only be …

Orofacial cleft and mandibular prognathism—human genetics and animal models

A Jaruga, J Ksiazkiewicz, K Kuzniarz… - International journal of …, 2022 - mdpi.com
Many complex molecular interactions are involved in the process of craniofacial
development. Consequently, the network is sensitive to genetic mutations that may result in …

Identification of Osr2 transcriptional target genes in palate development

X Fu, J Xu, P Chaturvedi, H Liu… - Journal of dental …, 2017 - journals.sagepub.com
Previous studies have identified the odd-skipped related 2 (Osr2) transcription factor as a
key intrinsic regulator of palatal shelf growth and morphogenesis. However, little is known …

The Function and Regulatory Network of Pax9 Gene in Palate Development

R Li, Z Chen, Q Yu, M Weng… - Journal of dental …, 2019 - journals.sagepub.com
Cleft palate, a common congenital deformity, can arise from disruptions in any stage of
palatogenesis, including palatal shelf growth, elevation, adhesion, and fusion. Paired box …

A new theory on the evaluation of traditional Chinese acupuncture mechanisms from the latest medical scientific point of view

BB Inanç - Acupuncture & electro-therapeutics research, 2015 - ingentaconnect.com
Acupuncture is a key component of traditional Chinese medicine involving the insertion of
needles through the skin at specific points on the body to achieve therapeutic effects and is …

[HTML][HTML] Altered FGF signaling pathways impair cell proliferation and elevation of palate shelves

W Wu, S Gu, C Sun, W He, X Xie, X Li, W Ye, C Qin… - PLoS …, 2015 - journals.plos.org
In palatogenesis, palatal shelves are patterned along the mediolateral axis as well as the
anteroposterior axis before the onset of palatal fusion. Fgf10 specifically expressed in lateral …

Assessing the association between hypoxia during craniofacial development and oral clefts

EC Küchler, LA Silva, P Nelson-Filho… - Journal of Applied Oral …, 2018 - SciELO Brasil
Objectives To evaluate the association between hypoxia during embryo development and
oral clefts in an animal model, and to evaluate the association between polymorphisms in …