Heterochromatin plays a fundamental role in gene regulation, genome integrity, and
silencing of repetitive DNA elements. Histone modifications are essential for the …

Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Compacted, transcriptionally repressed chromatin, referred to as heterochromatin,
represents a major fraction of the higher eukaryotic genome and exerts pivotal functions of …

A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …

Over the last decade,∼ 20–30 nucleotide RNA molecules have emerged as critical
regulators in the expression and function of eukaryotic genomes. Two primary categories of …

The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and
the subsequent recruitment of chromodomain proteins such as heterochromatin protein …

Small RNAs of 20–30 nucleotides guide regulatory processes at the DNA or RNA level in a
wide range of eukaryotic organisms. Many, although not all, small RNAs are processed from …

Small RNA molecules of about 20–30 nucleotides have emerged as powerful regulators of
gene expression and genome stability. Studies in fission yeast and multicellular organisms …

Nuclear transcription is not restricted to genes but occurs throughout the intergenic and
noncoding space of eukaryotic genomes. The functional significance of this widespread …