Recent experiments have revealed surprising behavior in the yeast galactose (GAL)
pathway, one of the preeminent systems for studying gene regulation. Under certain …

Natural selection dictates that cells constantly adapt to dynamically changing environments
in a context-dependent manner. Gene-regulatory networks often mediate the cellular …

We describe Dizzy, a software tool for stochastically and deterministically modeling the
spatially homogeneous kinetics of integrated large-scale genetic, metabolic, and signaling …

Like engineering systems, biological systems must also operate effectively in the presence
of internal and external uncertainty—such as genetic mutations or temperature changes, for …

Transcriptional noise is known to be an important cause of cellular heterogeneity and
phenotypic variation. The extent to which molecular interaction networks may have evolved …

Transcriptional noise is known to play a crucial role in heterogeneity in bacteria and yeast.
Mammalian macrophages are known to exhibit cell-to-cell variation in their responses to …

Positive and negative feedback loops, for example, where a protein regulates its own
transcription, play an important role in many genetic regulatory networks. Such systems will …

Publisher Summary Systems biological models aim at a detailed account of the dynamics of
complex biological systems, where “detailed” means that not only basic qualitative …

Bond graphs can be used to build thermodynamically‐compliant hierarchical models of
biomolecular systems. As bond graphs have been widely used to model, analyse and …

Functionally related genes tend to be chromosomally clustered in eukaryotic genomes even
after the exclusion of tandem duplicates, but the biological significance of this widespread …