Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …

In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in
tumor initiation and progression, shaped by complex interactions between cancer cells and …

Metastasis is a major contributor of death in cancer patients, and there is an urgent need for
effective treatments of metastatic malignancies. Herein, ketoprofen (KP) and loxoprofen (LP) …

The skin is the largest organ in the human body, providing a barrier to the external
environment. It is composed of three layers: epidermis, dermis and hypodermis. The most …

To develop new chemotherapeutics with anti-metastasis properties, a series of multi-specific
niflumic acid (NFA) platinum (IV) complexes with DNA damage, inflammation inhibition …

Diffuse glioma is one of the most prevalent malignancies of the brain, with high
heterogeneity of tumor-infiltrating immune cells. However, immune-associated subtypes of …

To develop a next-generation metal agent and dual-agent multitargeted combination
therapy, we developed a copper (Cu) compound based on the properties of the human …

In 2013, recognizing that Colorectal Cancer (CRC) is the second leading cause of death by
cancer worldwide and that it was a neglected disease increasing rapidly in Mexico, the …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Background Immunotherapy has revolutionized the treatment of ovarian cancer (OC), but
different immune microenvironments often constrain the efficacy of immunotherapeutic …