Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Regeneration of meniscus tissue using adipose mesenchymal stem cells-chondrocytes co-culture on a hybrid scaffold: In vivo study

L Moradi, M Vasei, MM Dehghan, M Majidi… - Biomaterials, 2017 - Elsevier
The meniscus has poor intrinsic regenerative capacity and its damage inevitably leads to
articular cartilage degeneration. We focused on evaluating the effects of Polyvinyl …

3D gelatin-chitosan hybrid hydrogels combined with human platelet lysate highly support human mesenchymal stem cell proliferation and osteogenic differentiation

F Re, L Sartore, V Moulisova… - Journal of tissue …, 2019 - journals.sagepub.com
Bone marrow and adipose tissue human mesenchymal stem cells were seeded in highly
performing 3D gelatin–chitosan hybrid hydrogels of varying chitosan content in the presence …

Trachea transplantation: from laboratory to patient

C Crowley, M Birchall… - Journal of tissue …, 2015 - Wiley Online Library
Abstract Today, tracheal lesions occupying< 30% of the trachea in children and< 50% in
adults can be treated with primary resection, followed by end‐to‐end anastomosis …

Migrational changes of mesenchymal stem cells in response to cytokines, growth factors, hypoxia, and aging

Y Naaldijk, AA Johnson, S Ishak, HJ Meisel… - Experimental cell …, 2015 - Elsevier
Mesenchymal stem cells (MSCs) are non-immunogenic, multipotent cells with at least
trilineage differentiation potential. They promote wound healing, improve regeneration of …

Endothelial differentiation of human stem cells seeded onto electrospun polyhydroxybutyrate/polyhydroxybutyrate-co-hydroxyvalerate fiber mesh

A Zonari, S Novikoff, NRP Electo, NM Breyner… - PLoS …, 2012 - journals.plos.org
Tissue engineering is based on the association of cultured cells with structural matrices and
the incorporation of signaling molecules for inducing tissue regeneration. Despite its …

New PLGA–P188–PLGA matrix enhances TGF-β3 release from pharmacologically active microcarriers and promotes chondrogenesis of mesenchymal stem cells

M Morille, T Van-Thanh, X Garric, J Cayon… - Journal of controlled …, 2013 - Elsevier
The use of injectable scaffolding materials for in vivo tissue regeneration has raised great
interest in various clinical applications because it allows cell implantation through minimally …

Modulation of osteogenic activity of BMP-2 by cellulose and chitosan derivatives

D Peschel, K Zhang, S Fischer, T Groth - Acta biomaterialia, 2012 - Elsevier
Polysaccharides with structure and potential bioactivity similar to heparin were synthesized
based on cellulose which was regioselectively sulfated, carboxylated or carboxymethylated …

Recent development of biomaterials combined with mesenchymal stem cells as a strategy in cartilage regeneration

J Chen - International Journal of Translational Medicine, 2022 - mdpi.com
Osteoarthritis leads to the progressive decay of articular cartilage. Due to its intrinsic
avascular character, cartilage shows an inadequate capacity for regeneration. Cartilage loss …