Museum of spatial transcriptomics

L Moses, L Pachter - Nature methods, 2022 - nature.com
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Immune response in COVID-19: what is next?

Q Li, Y Wang, Q Sun, J Knopf, M Herrmann… - Cell Death & …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

JW Guarnieri, JM Dybas, H Fazelinia, MS Kim… - Science translational …, 2023 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

TM Delorey, CGK Ziegler, G Heimberg, R Normand… - Nature, 2021 - nature.com
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

JJ Frere, RA Serafini, KD Pryce, M Zazhytska… - Science translational …, 2022 - science.org
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection can result in prolonged pathologies collectively referred to as post-acute sequalae …

Towards population-scale long-read sequencing

W De Coster, MH Weissensteiner… - Nature Reviews …, 2021 - nature.com
Long-read sequencing technologies have now reached a level of accuracy and yield that
allows their application to variant detection at a scale of tens to thousands of samples …

[HTML][HTML] In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

NAP Lieberman, V Peddu, H Xie, L Shrestha… - PLoS …, 2020 - journals.plos.org
Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …

Spatial omics technologies at multimodal and single cell/subcellular level

J Park, J Kim, T Lewy, CM Rice, O Elemento… - Genome Biology, 2022 - Springer
Spatial omics technologies enable a deeper understanding of cellular organizations and
interactions within a tissue of interest. These assays can identify specific compartments or …

Diagnostic techniques for COVID-19 and new developments

E Sheikhzadeh, S Eissa, A Ismail, M Zourob - Talanta, 2020 - Elsevier
COVID-19 pandemic is a serious global health issue today due to the rapid human to human
transmission of SARS-CoV-2, a new type of coronavirus that causes fatal pneumonia. SARS …

Enhancing colorimetric loop-mediated isothermal amplification speed and sensitivity with guanidine chloride

Y Zhang, G Ren, J Buss, AJ Barry, GC Patton… - …, 2020 - Taylor & Francis
Loop-mediated isothermal amplification (LAMP) is a versatile technique for detection of
target DNA and RNA, enabling rapid molecular diagnostic assays with minimal equipment …