Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

Adipose-derived stem cells (ADSCs) have raised big interest in therapeutic applications in
regenerative medicine and appear to fulfill the criteria for a successful cell therapy. Their low …

Genomic and functional study of existing and emerging sarcoma targets, such as fusion
proteins, chromosomal aberrations, reduced tumor suppressor activity, and oncogenic …

Sarcoma subtype classification is currently mainly based upon histopathological
morphology. Molecular analyses have emerged as an efficient addition to the diagnostic …

Cell mediated delivery of synthetic nano-and microparticle based drug carriers is a very
promising strategy to enhance control over the distribution of drugs and improve targeting …

Background Cell-based regenerative medicine therapies are now frequently tested in
clinical trials. In many conditions, cell therapies are administered systemically, but there is …

Bone defects may impede normal biomechanics and the structural stability of bone as an
organ. In many cases, the correction of bone defects requires extensive surgical intervention …

Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder
manifested by memory loss and cognitive impairment. Deposition of the amyloid β plaques …

Sarcomas represent an extensive group of divergent malignant diseases, with the only
common characteristic of being derived from mesenchymal cells. As such, sarcomas are by …

Aging is considered as inevitable changes at different levels of genome, cell, and organism.
From the accumulation of DNA damages to imperfect protein homeostasis, altered cellular …