Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

The establishment and maintenance of the vascular system is critical for embryonic
development and postnatal life. Defects in endothelial cell development and vessel …

Hematopoietic stem cells (HSCs) develop from a specialized subpopulation of endothelial
cells known as hemogenic endothelium (HE). Although the HE origin of HSCs is now well …

Advancing pluripotent stem cell technologies for modelling haematopoietic stem cell
development and blood therapies requires identifying key regulators of haematopoietic …

Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously
replenish all blood and immune cells during the lifetime of an individual,. HSCs are used …

Abstract Etv2 (Ets Variant 2) has been shown to be an indispensable gene for the
development of hematopoietic cells (HPCs)/endothelial cells (ECs). However, how Etv2 …

Haematopoietic stem cells (HSCs) are tissue-specific stem cells that replenish all mature
blood lineages during the lifetime of an individual. Clinically, HSCs form the foundation of …

Embryonic definitive hematopoiesis generates hematopoietic stem and progenitor cells
(HSPCs) essential for establishment and maintenance of the adult blood system. This …

Hematopoietic stem cells (HSC s) require multiple molecular inputs for proper specification,
including activity of the Notch signaling pathway. A requirement for the Notch1 and …

Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all
blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By …