Impact of childhood malnutrition on host defense and infection
MK Ibrahim, M Zambruni, CL Melby… - Clinical microbiology …, 2017 - Am Soc Microbiol
The global impact of childhood malnutrition is staggering. The synergism between
malnutrition and infection contributes substantially to childhood morbidity and mortality …
malnutrition and infection contributes substantially to childhood morbidity and mortality …
Leptin functions in infectious diseases
Leptin, a pleiotropic protein has long been recognized to play an important role in the
regulation of energy homeostasis, metabolism, neuroendocrine function, and other …
regulation of energy homeostasis, metabolism, neuroendocrine function, and other …
Pathologic inflammation in malnutrition is driven by proinflammatory intestinal microbiota, large intestine barrier dysfunction, and translocation of bacterial …
Acute malnutrition, or wasting, is implicated in over half of all deaths in children under five
and increases risk of infectious disease. Studies in humans and preclinical models have …
and increases risk of infectious disease. Studies in humans and preclinical models have …
New insights into leishmaniasis in the immunosuppressed
H Akuffo, C Costa, J van Griensven… - PLoS neglected …, 2018 - journals.plos.org
Immunosuppression contributes significantly to the caseload of visceral leishmaniasis (VL).
HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the …
HIV coinfection, solid organ transplantation, malnutrition, and helminth infections are the …
Overcoming roadblocks in the development of vaccines for leishmaniasis
PM Kaye, S Mohan, C Mantel, M Malhame… - Expert Review of …, 2021 - Taylor & Francis
Introduction The leishmaniases represent a group of parasitic diseases caused by infection
with one of several species of Leishmania parasites. Disease presentation varies because …
with one of several species of Leishmania parasites. Disease presentation varies because …
Thymus, undernutrition, and infection: approaching cellular and molecular interactions
W Savino, J Durães, C Maldonado-Galdeano… - Frontiers in …, 2022 - frontiersin.org
Undernutrition remains a major issue in global health. Low protein-energy consumption,
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …
results in stunting, wasting and/or underweight, three deleterious forms of malnutrition that …
Inflammatory stimuli alter bone marrow composition and compromise bone health in the malnourished host
EY Osorio, Z Gugala, GT Patterson, G Palacios… - Frontiers in …, 2022 - frontiersin.org
Inflammation has a role in the pathogenesis of childhood malnutrition. We investigated the
effect of malnutrition and inflammatory challenge on bone marrow composition and bone …
effect of malnutrition and inflammatory challenge on bone marrow composition and bone …
Malnutrition disrupts adaptive immunity during visceral leishmaniasis by enhancing IL-10 production
L Amorim Sacramento, C Gonzalez-Lombana… - PLoS …, 2024 - journals.plos.org
Protein-energy malnutrition (PEM) is a risk factor for developing visceral leishmaniasis (VL).
While nutrient deficiency can impair immunity, its mechanistic impact on protective adaptive …
While nutrient deficiency can impair immunity, its mechanistic impact on protective adaptive …
Malnutrition-related parasite dissemination from the skin in visceral leishmaniasis is driven by PGE2-mediated amplification of CCR7-related trafficking of infected …
EY Osorio, A Uscanga-Palomeque… - PLoS neglected …, 2023 - journals.plos.org
People are infected with Leishmania donovani when the parasite is deposited in the dermis
during the blood meal of the sand fly vector. Most infected people develop a subclinical …
during the blood meal of the sand fly vector. Most infected people develop a subclinical …
Tissue tropism: Is it an intrinsic characteristic of Leishmania species?
IA Maatallah, K Akarid, M Lemrani - Acta Tropica, 2022 - Elsevier
The genus Leishmania comprises a wide range of species, some of which are pathogenic to
humans and each of which has a different tissue preference, resulting in one of the three …
humans and each of which has a different tissue preference, resulting in one of the three …