Human surfactant protein SP-A1 and SP-A2 variants differentially affect the alveolar microenvironment, surfactant structure, regulation and function of the alveolar …
J Floros, N Thorenoor, N Tsotakos… - Frontiers in …, 2021 - frontiersin.org
The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect
survival after infection in mice and in lung transplant patients. SP-A interacts with the …
survival after infection in mice and in lung transplant patients. SP-A interacts with the …
Differential regulation of human surfactant protein A genes, SFTPA1 and SFTPA2, and their corresponding variants
J Floros, N Tsotakos - Frontiers in immunology, 2021 - frontiersin.org
The human SFTPA1 and SFTPA2 genes encode the surfactant protein A1 (SP-A1) and SP-
A2, respectively, and they have been identified with significant genetic and epigenetic …
A2, respectively, and they have been identified with significant genetic and epigenetic …
Single nucleotide polymorphisms interactions of the surfactant protein genes associated with respiratory distress syndrome susceptibility in preterm infants
S Amatya, M Ye, L Yang, CK Gandhi, R Wu… - Frontiers in …, 2021 - frontiersin.org
Background: Neonatal respiratory distress syndrome (RDS), due to surfactant deficiency in
preterm infants, is the most common cause of respiratory morbidity. The surfactant proteins …
preterm infants, is the most common cause of respiratory morbidity. The surfactant proteins …
SNP and haplotype interaction models reveal association of surfactant protein gene polymorphisms with hypersensitivity pneumonitis of Mexican population
Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by
inhalation of common environmental organic particles. Surfactant proteins (SPs) play a role …
inhalation of common environmental organic particles. Surfactant proteins (SPs) play a role …
Evolution of multiple omics approaches to define pathophysiology of pediatric acute respiratory distress syndrome
Pediatric acute respiratory distress syndrome (PARDS), though both common and deadly in
critically ill children, lacks targeted therapies. The development of effective …
critically ill children, lacks targeted therapies. The development of effective …
SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children
We studied associations of persistent respiratory morbidity (PRM) at 6 and 12 months after
acute respiratory failure (ARF) in previously healthy children with single-nucleotide …
acute respiratory failure (ARF) in previously healthy children with single-nucleotide …
Single nucleotide polymorphisms (SNP) and SNP-SNP interactions of the surfactant protein genes are associated with idiopathic pulmonary fibrosis in a Mexican …
Surfactant proteins (SPs) are important for normal lung function and innate immunity of the
lungs and their genes have been identified with significant genetic variability. Changes in …
lungs and their genes have been identified with significant genetic variability. Changes in …
Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children
The severity of respiratory syncytial virus (RSV) may be linked to host genetic susceptibility.
Surfactant protein (SP) genetic variants have been associated with RSV severity, but the …
Surfactant protein (SP) genetic variants have been associated with RSV severity, but the …
ENaC gene variants and their involvement in Covid‑19 severity
E Koniari, K Hatziagapiou, AO Nikola… - Biomedical …, 2024 - spandidos-publications.com
Epidemiological studies report the association of diverse cardiovascular conditions with
coronavirus disease 2019 (COVID-19), but the causality has remained to be established …
coronavirus disease 2019 (COVID-19), but the causality has remained to be established …
Unraveling the enigma: The emerging significance of pulmonary surfactant proteins in predicting, diagnosing, and managing COVID‐19
MN Bastani, S Jalilian - Immunity, Inflammation and Disease, 2024 - Wiley Online Library
Background Severe cases of COVID‐19 often lead to the development of acute respiratory
syndrome, a critical condition believed to be caused by the harmful effects of SARS‐CoV‐2 …
syndrome, a critical condition believed to be caused by the harmful effects of SARS‐CoV‐2 …