This paper presents an overview of the research progress in deterministic global
optimization during the last decade (1998–2008). It covers the areas of twice continuously …

Mathematical modeling, simulation and optimization techniques had a great impact in the
history of mankind and helped to understand and improve many processes of different kinds …

Background Kinetic models of biochemical systems usually consist of ordinary differential
equations that have many unknown parameters. Some of these parameters are often …

Background Dynamic modelling provides a systematic framework to understand function in
biological systems. Parameter estimation in nonlinear dynamic models remains a very …

An enhanced scatter search method for the global dynamic optimization of nonlinear
processes using the control vector parametrization (CVP) approach is presented. Sharing …

Mathematical modeling of HIV‐1 infection has proven to be instrumental for the modern
understanding basis of the AIDS pathogenesis, since it offers the unique means to …

Optimal design and control of industrially important chemical processes rely on dynamic
optimization. However, because of the highly constrained, nonlinear, and sometimes …

Many practical optimal control problems include discrete decisions. These may be either
time-independent parameters or time-dependent control functions as gears or valves that …

Accurate quantitative chemical kinetic models are useful in many applications, ranging from
design of chemical processes to building a consensus for international treaties (eg the …

This contribution gives an overview on the state-of-the-art and recent advances in mixed
integer optimization to solve planning and design problems in the process industry. In some …