Abstract In 2010, the World Health Organization (WHO) classification of neuroendocrine
neoplasms was reviewed and validated the crucial role of the proliferative rate. According to …

Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine
differentiation, can arise in various organs. NENs have been divided into well-differentiated …

R. Garcia-Carbonero a H. Sorbye b E. Baudin c E. Raymond d B. Wiedenmann e B. Niederle
f E. Sedlackova g C. Toumpanakis h M. Anlauf i JB Cwikla j M. Caplin k D. O'Toole l A …

High-grade neuroendocrine neoplasms are a rare disease entity and account for
approximately 10% of all neuroendocrine neoplasms. Because of their rarity, there is an …

To date, empirical literature has generally been considered lacking in relation to
neuroendocrine carcinomas (NECs), the highly malignant subgroup of neuroendocrine …

Systemic chemotherapy is indicated in progressive or bulky advanced pancreatic
neuroendocrine tumors (NETs) and in grade 3 (G3) neuroendocrine neoplasms (NENs) as …

Background Platinum‐based chemotherapy is recommended for the treatment of advanced
gastroenteropancreatic neuroendocrine carcinoma (GEP‐NEC). The objective of the current …

Progress in the diagnostics and therapy of gastro-entero-pancreatic (GEP) neuroendocrine
neoplasms (NEN), the published results of new randomised clinical trials, and the new …

Background Poorly differentiated neuroendocrine carcinomas (NECs) are rare and
aggressive tumors. Their molecular pathogenesis is still largely unknown, and consequently …

Opinion statement Treatment recommendations for advanced gastroenteropancreatic
neuroendocrine carcinomas (GEP-NEC) are based on uncontrolled, mainly retrospective …