Strategies for targeting gene therapy in cancer cells with tumor-specific promoters

M Montaño-Samaniego, DM Bravo-Estupiñan… - Frontiers in …, 2020 - frontiersin.org
Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases,
due to the lack of early diagnosis, and high relapse rate after conventional therapies …

Near-infrared light-triggered nano-prodrug for cancer gas therapy

R Liu, Y Peng, L Lu, S Peng, T Chen… - Journal of …, 2021 - Springer
Gas therapy (GT) has attracted increasing attention in recent years as a new cancer
treatment method with favorable therapeutic efficacy and reduced side effects. Several gas …

Photoactivatable prodrug-backboned polymeric nanoparticles for efficient light-controlled gene delivery and synergistic treatment of platinum-resistant ovarian cancer

Q Zhang, G Kuang, S He, H Lu, Y Cheng, D Zhou… - Nano …, 2020 - ACS Publications
Combination of chemotherapy and gene therapy provides an effective strategy for cancer
treatment. However, the lack of suitable codelivery systems with efficient endo/lysosomal …

Photochemical internalization for intracellular drug delivery. From basic mechanisms to clinical research

W Jerjes, TA Theodossiou, H Hirschberg… - Journal of clinical …, 2020 - mdpi.com
Photochemical internalisation (PCI) is a unique intervention which involves the release of
endocytosed macromolecules into the cytoplasmic matrix. PCI is based on the use of …

Photodynamic therapy with smart nanomedicine

J Kim, Y Jo, K Na - Archives of pharmacal research, 2020 - Springer
For several decades, clinical demands for utilization of photodynamic therapy (PDT) have
been increasing. Notably, PDT was mainly applied for cancer therapy, and most …

TRAIL-based gene delivery and therapeutic strategies

H Zhong, H Wang, J Li, Y Huang - Acta Pharmacologica Sinica, 2019 - nature.com
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), also known as APO2L,
belongs to the tumor necrosis factor family. By binding to the death receptor 4 (DR4) or DR5 …

A review of nanoparticle drug delivery systems responsive to endogenous breast cancer microenvironment

T Zou, W Lu, Y Mezhuev, M Lan, L Li, F Liu… - European Journal of …, 2021 - Elsevier
Breast cancer, as a malignant disease that seriously threatens women's health, urgently
needs to be researched to develop effective and safe therapeutic drugs. Nanoparticle drug …

Tailor‐made nanomaterials for diagnosis and therapy of pancreatic ductal adenocarcinoma

X Hu, F Xia, J Lee, F Li, X Lu, X Zhuo, G Nie… - Advanced …, 2021 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to
its aggressiveness and the challenge to early diagnosis and treatment. In recent decades …

Mesenchymal stromal cell-based targeted therapy pancreatic cancer: Progress and challenges

Z Ma, J Hua, J Liu, B Zhang, W Wang, X Yu… - International Journal of …, 2023 - mdpi.com
Pancreatic cancer is an aggressive malignancy with high mortality rates and poor
prognoses. Despite rapid progress in the diagnosis and treatment of pancreatic cancer, the …

Emerging role of mesenchymal stromal cells in gynecologic cancer therapy

Y Song, H Liu, S Pan, X Xiang, M Ye, X Zhu - Stem Cell Research & …, 2023 - Springer
Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine
with superior anti-fibrotic, immunomodulatory, and angiogenic functions. More recently …