Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Abstract NONCODE (http://www. noncode. org/) is a comprehensive database of collection
and annotation of noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals …

The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

Plants have an extraordinary diversity of transcription machineries, including five nuclear
DNA-dependent RNA polymerases. Four of these enzymes are dedicated to the production …

The central dogma of gene expression propounds that DNA is transcribed to mRNA and
finally gets translated into protein. Only 2–3% of the genomic DNA is transcribed to protein …

The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

AS (alternative splicing) is a fundamental process by which a gene can generate multiple
distinct mRNA transcripts to increase protein diversity. Defects in AS influence the …