Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Mechanical stimuli play a major role in the regulation of skeletal muscle mass, and the
maintenance of muscle mass contributes significantly to disease prevention and issues …

Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that exhibits pleiotrophic
biological activities, ranging from rapid morphological changes to long-term cellular effects …

Lipid phosphate phosphatases (LPPs) are a group of enzymes that belong to a
phosphatase/phosphotransferase family. Mammalian LPPs consist of three isoforms: LPP1 …

Phosphatidate phosphohydrolase (PAP) 1 was first identified as being involved in
glycerolipid synthesis (1). A second PAP activity (PAP-2) was subsequently characterized in …

Phospholipids and sphingolipids play critical roles in signal transduction, intracellular
membrane trafficking, and control of cell growth and survival. We discuss recent progress in …

Ovarian cancer is the most frequent cause of cancer death among all gynecologic cancers.
We demonstrate here that lysophosphatidic acid (LPA)-induced ectodomain shedding of …

Lipid phosphate phosphatases (LPPs) are a family of integral membrane glycoproteins that
catalyze the dephosphorylation of a number of bioactive lipid mediators including …

Two genes in Saccharomyces cerevisiae, LPP1 and DPP1, with homology to a mammalian
phosphatidic acid (PA) phosphatase were identified and disrupted. Neither single nor …

Lipid phosphate phosphohydrolase (LPP)-1 cDNA was cloned from a rat liver cDNA library.
It codes for a 32-kDa protein that shares 87 and 82% amino acid sequence identities with …