The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …

Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary
sclerosing cholangitis (PSC), are associated with bile stasis and gradually progress to …

Cellular senescence is a mechanism that provides an irreversible barrier to cell cycle
progression to prevent undesired proliferation. However, under pathological circumstances …

The main trigger for liver injury in acquired cholestatic liver disease remains unclear.
However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in …

Senescence is a durable cell cycle arrest that can be induced in response to various stress
factors, such as telomere erosion, DNA damage or the aberrant activation of oncogenes. In …

Substance P (SP) is involved in the proliferation of cholangiocytes in bile duct–ligated (BDL)
mice and human cholangiocarcinoma growth by interacting with the neurokinin‐1 receptor …

Background and Aims Apelin (APLN) is the endogenous ligand of its G protein–coupled
receptor, apelin receptor (APJ). APLN serum levels are increased in human liver diseases …

Cholangiocytes, epithelial cells that line the biliary epithelium, are the primary target cells for
cholangiopathies including primary sclerosing cholangitis and primary biliary cholangitis …

Primary sclerosing cholangitis (PSC) is an idiopathic cholangiopathy strongly associated
with inflammatory bowel disease (IBD) and characterized by cholestasis, chronic immune …