Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where
nascent proteins encounter a specialized environment for their folding and maturation …

Autosomal-dominant polycystic kidney disease (ADPKD) is a common, progressive, adult-
onset disease that is an important cause of end-stage renal disease (ESRD), which requires …

Dominantly inherited isolated polycystic liver disease (PCLD) consists of liver cysts that are
radiologically and pathologically identical to those seen in autosomal dominant polycystic …

The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated
in many human cancers and plays pivotal roles in tumor progression and therapy resistance …

The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic
processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and …

Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein
response (UPR), are triggered by the accumulation of unfolded and misfolded proteins …

IRE1 is an important central regulator of unfolded protein response (UPR) in the
endoplasmic reticulum (ER) because of its ability to regulate cell fate as a function of stress …

Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening monogenic
disease caused by mutations in PKD1 and PKD2 that encode polycystin 1 (PC1) and …

Polycystic kidney disease (PKD), comprising autosomal dominant polycystic kidney disease
(ADPKD) and autosomal recessive polycystic kidney d isease (ARPKD), is characterized by …