Advances and challenges in diagnostics of toxoplasmosis in HIV-infected patients

R Wesołowski, M Pawłowska, M Smoguła… - Pathogens, 2023 - mdpi.com
Toxoplasma gondii is a worldwide distributed protozoan parasite. This apicomplexan
parasite infects one-third of the population worldwide, causing toxoplasmosis, considered …

Modulation of autophagy as a therapeutic strategy for Toxoplasma gondii infection

A Cheng, H Zhang, B Chen, S Zheng… - Frontiers in Cellular …, 2022 - frontiersin.org
Toxoplasma gondii infection is a severe health threat that endangers billions of people
worldwide. T. gondii utilizes the host cell membrane to form a parasitophorous vacuole (PV) …

Metabolic changes in Toxoplasma gondii-infected host cells measured by autofluorescence imaging

GM Gallego-López, E Contreras Guzman, DE Desa… - Mbio, 2024 - journals.asm.org
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity …

Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone

C Wang, L Xie, Y Xing, M Liu, J Yang… - PLOS Neglected …, 2023 - journals.plos.org
Iron is a trace metal element that is essential for the survival of cells and parasites. The role
of iron in cerebral toxoplasmosis (CT) is still unclear. Deferiprone (DFP) is the orally active …

Immunomodulatory, Antioxidant, and Anti-Inflammatory Activities of Green Synthesized Copper Nanoparticles for Treatment of Chronic Toxoplasma gondii Infection

AD Alanazi, SF Alnomasy - Pharmaceuticals, 2023 - mdpi.com
Background: Nowadays, interest in the use of nanotechnology for medical purposes is
increasing. The current experimental investigation is planned for the green synthesis …

Mitochondria-selective dicationic small-molecule ligand targeting G-quadruplex structures for human colorectal cancer therapy

BX Zheng, W Long, W Zheng, Y Zeng… - Journal of medicinal …, 2024 - ACS Publications
Mitochondria are important drug targets for anticancer and other disease therapies. Certain
human mitochondrial DNA sequences capable of forming G-quadruplex structures (G4s) are …

Toxoplasma gondii infection affects the complete blood count and disturbs the markers of oxidative stress from the vital organs of wild rodents

M Ijaz, AU Khan, S Ullah, A Khan, S Ibenmoussa… - Scientific Reports, 2024 - nature.com
Rodents are the synanthropic mammals that are existing in close proximity to humans and
their belongings and have the potential to act as the reservoir for a variety of parasites …

[HTML][HTML] Molecular modelling and experimental validation identified a new therapeutic inhibitor of toxoplasmosis

OS Adeyemi, T Johnson, T Maduakolam-Aniobi… - Computers in Biology …, 2024 - Elsevier
Toxoplasmosis is a widespread parasitic disease, caused by Toxoplasma gondii, that affects
nearly one-third of the human population. The lack of effective treatments drives the demand …

Strategies of pathogens to escape from NO-based host defense

G De Simone, A di Masi, P Ascenzi - Antioxidants, 2022 - mdpi.com
Nitric oxide (NO) is an essential signaling molecule present in most living organisms
including bacteria, fungi, plants, and animals. NO participates in a wide range of biological …

Biogenic selenium nanoparticles: trace element with promising anti-toxoplasma effect

FM Arafa, NMFH Mogahed… - Pathogens and Global …, 2023 - Taylor & Francis
Toxoplasmosis is an opportunistic infection caused by the coccidian Toxoplasma gondii
which represents a food and water contaminant. The available chemotherapeutic agents for …