Altered intestinal permeability plays a role in many pathological conditions. Intestinal
permeability is a component of the intestinal barrier. This barrier is a dynamic interface …

Recent advances have contributed to a mechanistic understanding of neuroimmune
interactions in the intestine and revealed an essential role of this cross talk for gut …

Background The intestinal microbiota plays an important role in regulating gastrointestinal
(GI) physiology in part through interactions with the enteric nervous system (ENS) …

Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI)
tract. There is growing evidence that increases in intestinal permeability plays a pathogenic …

The gastrointestinal mucosal surface is lined with epithelial cells representing an effective
barrier made up with intercellular junctions that separate the inner and the outer …

Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a
vasodilator in 1970, has multiple physiological and pathological effects on development …

The microbiota-gut-brain axis or simple gut-brain axis (GBA) is a complex and interactive
bidirectional communication network linking the gut to the brain. Alterations in the …

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal ailments among
those seeking health care for gastrointestinal disorders. Despite its prevalence, IBS …

The intestinal epithelium, the largest interface between the host and environment, regulates
fluxes of ions and nutrients and limits host contact with the massive load of luminal antigens …

Background: Growing evidence suggests that patients with irritable bowel syndrome (IBS)
have increased intestinal permeability. In addition, mucosal soluble mediators are involved …