Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder

JM LaSalle - Molecular psychiatry, 2023 - nature.com
Autism spectrum disorder (ASD) comprises a heterogeneous group of neurodevelopmental
outcomes in children with a commonality in deficits in social communication and language …

The potential of DNA methylation as a biomarker for obesity and smoking

A Heikkinen, S Bollepalli… - Journal of internal …, 2022 - Wiley Online Library
DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …

Multi-omics signatures of the human early life exposome

L Maitre, M Bustamante, C Hernández-Ferrer… - Nature …, 2022 - nature.com
Environmental exposures during early life play a critical role in life-course health, yet the
molecular phenotypes underlying environmental effects on health are poorly understood. In …

Epigenetic alterations of maternal tobacco smoking during pregnancy: a narrative review

A Nakamura, O François, J Lepeule - International Journal of …, 2021 - mdpi.com
In utero exposure to maternal tobacco smoking is the leading cause of birth complications in
addition to being associated with later impairment in child's development. Epigenetic …

Linking prenatal environmental exposures to lifetime health with epigenome-wide association studies: state-of-the-science review and future recommendations

KM Bakulski, F Blostein, SJ London - Environmental health …, 2023 - ehp.niehs.nih.gov
Background: The prenatal environment influences lifetime health; epigenetic mechanisms
likely predominate. In 2016, the first international consortium paper on cigarette smoking …

Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes

LE Shorey-Kendrick, CT McEvoy, SM O'Sullivan… - Clinical …, 2021 - Springer
Background Maternal smoking during pregnancy (MSDP) affects development of multiple
organ systems including the placenta, lung, brain, and vasculature. In particular, children …

Epigenetics as a biomarker for early-life environmental exposure

R Schrott, A Song, C Ladd-Acosta - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review There is interest in evaluating the developmental origins of
health and disease (DOHaD) which emphasizes the role of prenatal and early-life …

A robust machine learning predictive model for maternal health risk

L Pawar, J Malhotra, A Sharma… - 2022 3rd international …, 2022 - ieeexplore.ieee.org
Maternal health refers to the physical, mental, and emotional well-being of mothers
throughout all stages of pregnancy, birth, and the postpartum period. Morbidity and death …

Quantitative identification of the co-exposure effects of e-waste pollutants on human oxidative stress by explainable machine learning

L Yang, T Zhang, Y Gao, D Li, R Cui, C Gu… - Journal of Hazardous …, 2024 - Elsevier
Global electronic waste (e-waste) generation continues to grow. The various pollutants
released during precarious e-waste disposal activities can contribute to human oxidative …

A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator

T Doherty, E Dempster, E Hannon, J Mill, R Poulton… - BMC …, 2023 - Springer
Background The field of epigenomics holds great promise in understanding and treating
disease with advances in machine learning (ML) and artificial intelligence being vitally …